Coronary Microvascular Rarefaction and Myocardial Fibrosis in Heart Failure with Preserved Ejection Fraction
نویسندگان
چکیده
Background—Characterization of myocardial structural changes in heart failure (HF) with
منابع مشابه
Letter by Edwards et al Regarding Article, "Coronary Microvascular Rarefaction and Myocardial Fibrosis in Heart Failure With Preserved Ejection Fraction".
BACKGROUND Characterization of myocardial structural changes in heart failure with preserved ejection fraction (HFpEF) has been hindered by the limited availability of human cardiac tissue. Cardiac hypertrophy, coronary artery disease (CAD), coronary microvascular rarefaction, and myocardial fibrosis may contribute to HFpEF pathophysiology. METHODS AND RESULTS We identified HFpEF patients (n=...
متن کاملMicrovascular dysfunction and cardiac fibrosis in heart failure with preserved ejection fraction: a case report
We report the case of a 55-year-old woman with heart failure with preserved ejection fraction (HFpEF), who presented with hypertensive urgency and pulmonary oedema. The patient was medically optimized and underwent cardiac catheterization revealing pulmonary hypertension, elevated pulmonary capillary wedge pressure, normal cardiac index, and non-obstructive coronary disease. Invasive evaluation...
متن کاملA novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation.
Over the past decade, myocardial structure, cardiomyocyte function, and intramyocardial signaling were shown to be specifically altered in heart failure with preserved ejection fraction (HFPEF). A new paradigm for HFPEF development is therefore proposed, which identifies a systemic proinflammatory state induced by comorbidities as the cause of myocardial structural and functional alterations. T...
متن کاملDiastolic dysfunction in patients with ischemic symptoms without obstructive coronary artery disease.
P eople with ischemic symptoms who have no angiographi-cally obstructive coronary artery disease (CAD) are at increased risk for major adverse cardiovascular outcomes (death, myocardial infarction, stroke, and heart failure) as compared with the general population. Previous investigation, much of it originating from the National Heart, Lung, and Blood Institute–funded Women's Ischemia Syndrome ...
متن کاملEffect of Exercise Training on Heart Rate Variability in Patients with Heart Failure After Percutaneous Coronary Intervention
Background: This study aims to evaluate the effect of exercise training on heart rate variability (HRV) and to determine the correlation between parameters of HRV and the ejection fraction in patients with heart failure after percutaneous coronary intervention.Material and Methods: Fifty patients with left ventricular ejection fraction ≤ 40% undergone percutaneous coronary intervention were r...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2014